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Recent Achievements

Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma

2024/02/23

On February 19, 2024, Professor Li Qingquan's team published a research paper entitled "Methanine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal cancer" in Cell Metabolism. Pericytes are heterogeneous mural cells surrounding blood vessels that ar...

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A team led by Professor Ker Yu has discovered a new mechanism of drug resistance in KRAS-mutant non-small cell lung cancer (NSCLC)

2024/01/18

KRAS is one of the most prevalent oncogenic drivers of human malignancy including lung cancer. Approximately 25% of NSCLC harbor the mutated KRAS gene (KRASmut), among which KRASG12C is the most common type in lung adenocarcinoma (LUAD). Tissue factor (TF) activation can greatly promote the malignan...

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Front Cover Article Published in Journal of Controlled Release: Ginsenoside Rg3 Endows Liposomes with Prolonged Blood Circulation and Reduced Accelerated Blood Clearance

2024/01/03

Recently, Professor Jianxin Wangs group at the School of Pharmacy, Fudan University, published a paper in the esteemed pharmaceutical journal, theJournal of Controlled Release, in 364thissue of 2023. The paper was titled Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced a...

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Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead

2023/12/19

Cancer metabolism plays multifaceted roles in the initiation and progression of tumors, and interventions in metabolism are considered fundamental approaches for cancer control. Within the vast metabolic networks of tumors, there exist numerous potential therapeutic targets, intricately interconnect...

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Assoc. Prof. Qiong Xie and Prof. Yonghui Wang’s group discovered a novel RORγt agonist candidate with great potential in cancer immunotherapy

2023/11/29

In recent years, the immune regulatory function of retinoic acid receptor related orphan receptor RORγt in tumor microenvironment (TME) has attracted considerable attentions, and RORγt has become a highly promising drug target for cancer immunotherapy. Some studies have demonstrated that T helper ...

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Prof. Lu Zhou's group reported a new method for high-throughput screening of covalent ligands

2023/11/29

The DNA-encoded chemical library (DEL) has emerged as a powerful technology for rapidly synthesizing and selecting library members. DELs incorporating an electrophile warhead, known as covalent DELs, have been utilized for covalent drug discovery. However, the use of these covalent DELs has been lim...

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Cover Story in J Chem Inf Model Magazine by Wang's Group: A Practical Tool for Predicting Hydration Sites and Estimating Desolvation Energy in Protein Binding Pockets - HydraMap v.2

2023/09/14

The recognition of water molecules' significance in protein-ligand binding is well-established among researchers. Examining pivotal water molecules can provide insights into "anomalous" structure-activity relationships and offer guidance for the efficient design of lead compounds. Whi...

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Professor Xiaoyan Shen's group discovered a novel potential drug target for treating inflammatory bowel disease by restoring intestinal stem cell stemness.

2023/09/07

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is characterized by chronic relapsing intestinal inflammation of unknown etiology. Studies suggest that genetic, environmental, and immunologic factors lead to disruption of the intestinal mucosal barr...

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Professor Cong Li's group proposes a new strategy for locating glioma invasive margins by visualizing immunosuppressed macrophages

2023/08/08

Gliomas are the most common intracranial primary malignant tumors, accounting for approximately 80% of all malignant brain tumors, and are characterized by high recurrence rates, high mortality rates, and low cure rates. Surgery is the preferred option for glioma treatment. However, due to the infil...

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A review by Dr Lu Wang on Angew Chem Int Ed: A new generation of fluorescent probes for high contrast labeling of target proteins

2023/07/25

In recent years, the rapid advancement of techniques such as super-resolution fluorescence imaging has provided unprecedented opportunities for the ultra-high spatiotemporal resolution visualization and biological functional research of target proteins. The high contrast labeling of target proteins ...

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Professor Lu Zhou's research group reported a novel mechanism to regulate HIF-1α transcriptional activity

2023/07/05

Maintenance of cellular oxygen homeostasis is essential for ensuring the normal life activities of cells. William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza shared 2019 Nobel Prize in Physiology or Medicine for discovering how cells sense and adapt to oxygen availability. Hypoxia inducible ...

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Variations in pre-hospital delays in stroke patients in China according to age, rurality, and province: a cross-sectional study

2023/05/10

Recently, a cross-sectional study on prehospital delays among the stroke population in China, based on the Bigdata Observatory Platform for Stroke of China (BOSC), has been published online in The Lancet Regional Health -Western Pacific. This is the first study to report variations in prehospital de...

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Prof. Chen Jiang's group has made progress in ROS/electro dual-reactive nanogel for targeting epileptic foci to remodel aberrant circuits and inflammatory microenvironment

2023/05/03

Recently, the research group led by Prof. Chen Jiang has reported a hydrogel nanoparticle drug delivery system, or namely nanogel, which is hopeful to address several problems facing the currently prevalent anti-epileptic drug therapies in epileptic treatment. The study was published online in ACS N...

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Professor Cong Li's Group Presents Comprehensive Review on Fluorescence Microscopy Platforms for Visualizing Mitochondrial Abnormalities in Neurodegenerative Diseases

2023/05/03

The growing global population and increasing longevity have led to a surge in neurodegenerative diseases (NDs), contributing to higher rates of morbidity and mortality. Neurodegenerative diseases like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD) sh...

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Prof. Wei Wu’s group proposed a new strategy for strengthening active targeting based on “Hook&Loop” type multivalent interactions

2023/04/28

Recently, Prof. Wei Wu’s group at Fudan University School of Pharmacy published a research article titled “ ‘Hook&Loop’ multivalent interactions based on disk-shaped nanoparticles strengthen active targeting” in Vol. 354, Journal of Controlled Release.

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Prof. Chen Jiang's group has made progress in transcytosis mediated permeable drug delivery for enhanced pancreatic cancer therapy

2023/04/14

Recently, the research group led by Prof. Chen Jiang has developed a versatile drug delivery system that can trigger transcytosis. The delivery system can efficiently deliver chemotherapy drugs to the deep tumor, regulate the microenvironment, and activate the anti-PDAC immune response. The study wa...

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Professor Xianyi Sha, School of Pharmacy/Professor Jing Zhao, Affiliated Minhang Hospital. AFM: Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke

2023/04/08

Ischemic stroke is a formidable disease with high morbidity, disability and fatality, which seriously threatens the life quality and health of patients. The clinically recommended treatment for ischemic stroke is intravenous thrombolysis or intra-arterial thrombectomy to timely restore the blood sup...

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Assoc. Prof. Qiong Xie and Prof. Yonghui Wang's research group reports selective and orally bioavailable adenosine A2A receptor antagonists for cancer immunotherapy

2023/03/30

In recent years, the tumor immune regulatory function of adenosine A2A receptor (A2AR) has attracted much attention, and A2AR has been identified as an emerging potential target for cancer immunotherapy. In the tumor microenvironment (TME), hypoxia upregulates the expression of CD39 and CD73 through...

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PNAS丨Progress in pan-sarbecovirus vaccines against SARS-CoV-2 Omicron subvariants from Zezhong Liu's research group

2023/03/14

The recently emerged Omicron subvariants XBB and BQ.1.1 have presented striking immune evasion against most monoclonal neutralizing antibodies and convalescent plasma.Even three or four doses of parental messenger RNA (mRNA) vaccine cannot induce strong neutralization against XBB.The antibody evasio...

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Prof. Chen Jiang's group has made progress in bioinspired drug delivery system in the treatment of acute ischemic stroke

2023/03/14

Recently, the research group led by Prof. Chen Jiang has developed a bioinspired nanoerythrocyte, which could modulate the metabolic microenvironment of the brain lesion area and was applied for the whole process of acute ischemic stroke (AIS) treatment. The related article was published online in ...

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Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma

A team led by Professor Ker Yu has discovered a new mechanism of drug resistance in KRAS-mutant non-small cell lung cancer (NSCLC)

Front Cover Article Published in Journal of Controlled Release: Ginsenoside Rg3 Endows Liposomes with Prolonged Blood Circulation and Reduced Accelerated Blood Clearance

Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead

Assoc. Prof. Qiong Xie and Prof. Yonghui Wang’s group discovered a novel RORγt agonist candidate with great potential in cancer immunotherapy

Prof. Lu Zhou's group reported a new method for high-throughput screening of covalent ligands

Cover Story in J Chem Inf Model Magazine by Wang's Group: A Practical Tool for Predicting Hydration Sites and Estimating Desolvation Energy in Protein Binding Pockets - HydraMap v.2

Professor Xiaoyan Shen's group discovered a novel potential drug target for treating inflammatory bowel disease by restoring intestinal stem cell stemness.

Professor Cong Li's group proposes a new strategy for locating glioma invasive margins by visualizing immunosuppressed macrophages

A review by Dr Lu Wang on Angew Chem Int Ed: A new generation of fluorescent probes for high contrast labeling of target proteins

Professor Lu Zhou's research group reported a novel mechanism to regulate HIF-1α transcriptional activity

Variations in pre-hospital delays in stroke patients in China according to age, rurality, and province: a cross-sectional study

Prof. Chen Jiang's group has made progress in ROS/electro dual-reactive nanogel for targeting epileptic foci to remodel aberrant circuits and inflammatory microenvironment

Professor Cong Li's Group Presents Comprehensive Review on Fluorescence Microscopy Platforms for Visualizing Mitochondrial Abnormalities in Neurodegenerative Diseases

Prof. Wei Wu’s group proposed a new strategy for strengthening active targeting based on “Hook&Loop” type multivalent interactions

Prof. Chen Jiang's group has made progress in transcytosis mediated permeable drug delivery for enhanced pancreatic cancer therapy

Professor Xianyi Sha, School of Pharmacy/Professor Jing Zhao, Affiliated Minhang Hospital. AFM: Drug-Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia-Reperfusion Therapy in Stroke

Assoc. Prof. Qiong Xie and Prof. Yonghui Wang's research group reports selective and orally bioavailable adenosine A2A receptor antagonists for cancer immunotherapy

PNAS丨Progress in pan-sarbecovirus vaccines against SARS-CoV-2 Omicron subvariants from Zezhong Liu's research group

Prof. Chen Jiang's group has made progress in bioinspired drug delivery system in the treatment of acute ischemic stroke